2019 A G E N D A  


T H U R S D A Y, S E P T E M B E R 5th

7:00AM-8:00AM       BREAKFAST and Exhibitor Zone

8:00AM-8:15AM       Welcome and Introduction 

 Conference Director:  Steve Feinstein

 Conference Co-Directors:  Stephanie Wilson and Petros  Nihoyannopoulos

8:15AM-9:15AM       CEUS Updates Around the World - SESSION I

Chairs: Stephanie Wilson and Petros Nihoyannopoulos

Regulatory Reports Globally

ICUS: Linda Feinstein, Robin Adams, 

FDA - Mike Main

IAC: Beverly Gorman

Li-RADS – Stephanie Wilson

EMA – WFUMB: Roxy Senior

FDA Perspectives on Research Study   

Designs for Evidence Generation - Stephanie Coquia

9:15AM-9:30AM       Stretch Break

9:30AM-11:00AM     CEUS Clinical Trials – SESSION II

Chairs: Anthony DeMaria and Anu Rao

Alfred Yu – Motion-Resistant (MORE) Visualization of the Microvasculature Using Contrast

Misun Hwang –Neonatal Updates

Kullervo  Hynynen - Ongoing Brain Cancer Therapy

Kassa Darge: Pediatric CEUS – Advancing Widespread Application

Dirk Clevert - Evaluating the Diagnostic Performance and Safety of Contrast-enhanced Ultrasound (CEUS) in Pregnant Women to Assess Hepatic Lesions.

11:00AM-11:45AM     BREAK and Exhibitor Zone

11:45AM-1:00PM       Gene Therapy – Session III                                                                                                   

Chairs: Folkert ten Cate and Beth McCarville

Paul Grayburn - Myocyte Regeneration with CEUS

Pintong Huang - Beta Cell Islet Regeneration and Normalization of Glycemic Control Through Glucagon-like Peptide-1 Gene Transfection by Ultrasound-Targeted Microbubble Destruction in Cynomolgus Macaque with Type 2 Diabetes Mellitus: A Pilot Study

Jonathan Lindner –Vascular Gene Delivery with Cationic Microbubble Vectors

Howard Leong Poi – miRNA Delivery in Acute MI/Ischemia-Reperfusion, and  an Rx for AAA

Liza Villanueva - Ultrasound and Microbubble-targeted Delivery of a microRNA Inhibitor to the Heart Suppresses Cardiac Hypertrophy and Preserves Cardiac Function

1:00PM-2:00PM         Lunch and Exhibitor Zone

2:00PM-3:00PM         CEUS - SESSION IV

Chairs: Thomas Grant and Ed Grant

Amer Johri –Intraplaque Neovascularization:  The Emerging Role of Contrast in the Assessment of Carotid Arterial Plaque for Cardiovascular Risk Stratification

Yuko Kono  –Contrast-Enhanced Ultrasound (CEUS) in the Evaluation and Diagnosis of Active Intra-Abdominal Bleeding in Cirrhotic Patients with Ascites

Henrik Sillesen –  Is Contrast Important for Determining Carotid Plaque Morphology?

John Eisenbrey - Augmenting HCC Radioembolization with UTMD: Clinical Trial Update

3:00PM-4:00PM          Pre-Clinical and Clinical Trials/Novel CEUS Applications  – SESSION V

Chairs: Harvey Feigenbaum and Sharon Mulvagh

Mengxing Tang -Super-resolution ultrasound imaging

Flemming Forsberg - Diagnosing Portal Hypertension with Subharmonic Pressure Estimates

Luciano Agati – Intra-ventricular Flow Patterns Assessment Before and After MitraClip Implantation in Patients with Functional Mitral Regurgitation

Wilson Mathias, Jr - Preclinical Studies Have Demonstrated that High Mechanical Index (MI) Impulses from a Diagnostic Ultrasound Transducer During an Intravenous Microbubble Infusion (Sonothrombolysis) Can Restore Epicardial and Microvascular Flow in Acute ST-segment Elevation Myocardial Infarction (STEMI)

4:00PM-4:45PM        BREAK and Exhibitor Zone

4:45PM-6:00PM        Session VI - Advanced Clinic Applications

Chairs: Dan Adam and Mike Main

Harald Becher – Edmonton Sonothrombolysis Pilot Study. Feasiblity
and Safety in Patients with a ST-segment Elevation Myocardial

Hessel Wijkstra – Clinical Validation of Multi-parametric MRI (mpMRI), Contrast Dispersion Imaging (CUDI) and Multi-parametric Ultrasound (mpUS) for Prostate Cancer.

Massimo Mischi –Prostate Cancer Diagnosis by Machine Learning and Targeted Nanobubbles.

Stephanie Wilson – Discordance of Enhancement in the PVP between CEMR and CEUS: Can this feature Improve Differentiation of HCC from ICC on Imaging? 

7:00PM-10:00PM      Thursday Night Social Event

F R I D A Y, S E P T E M B E R 6th

8:00AM-9:00AM       Novel Acoustic Imaging - SESSION VII

Chairs: Franco Pizzuto and Andy Appis

Otto Kamp - Microvascular Recovery Using Contrast Ultrasound in ST-elevation Myocardial infarction in the Ambulance (MRUSMI Ambulance)

Tom Porter -The Effect of Diagnostic Ultrasound Mediated Sonothrombolysis Applied Immediately After Emergent Percutaneous Coronary Artery Intervention in Acute Left Anterior Descending ST Segment Elevation Myocardial Infarction: Preliminary Observations 

Anthony DeMaria - New “Small Microbubbles”

Brett Angel - Novel Applications of Novel Microbubbles

9:00AM-9:45 AM        Acoustics – SESSION VIII

Chairs: James Miller and Seth Powsner

Mike Averkiou -  Image-guided Doxorubicin Delivery with Ultrasound and Microbubbles in a Mouse Model of Hepatocellular Carcinoma Using a Diagnostic Ultrasound System

Evan Unger – Fibrin Targeted Phase Change Nanodroplets for the Detection and Disruption of Fibrin Clots.

9:45AM-10:30AM       BREAK and Exhibitor Zone

10:30AM-11:30AM    CEUS Cellular Physiology – SESSION IX

Chairs: Arend Schinkel and Mark Monaghan

Klazina Kooiman – Relation Between Sonoporation and Opening of Intercellular Junctions for Microbubble-mediated Vascular Drug Delivery

John Pacella – Sonoreperfusion for the Treatment of Microvascular Obstruction

Rik Vos – High Frame Rate Microbubble-enhanced Velocimetry

11:30AM-12:30PM     LUNCH and Exhibitor Zone

12:30PM-1:30PM       Expert Case Presentations - SESSION X

Chairs: Folkert ten Cate and  Len Greenbaum and Paolo Voci

Ken Ford

Mark Monaghan

Arnaldo Rabischoffsky 

Roxy Senior 

Tom Grant

1:30PM-3:00PM         Wrap Up Panel Discussions – SESSION XI

Chairs: Petros Nihoyannopoulos and Sharon Mulvagh

Panelists:  Payman Sattar, Tochi Okwuosa, Andy Appis, Charlotte Bai, Alan Goldberg, Ali Khan